In recent years, a injectable skin care treatment called “RE20 Collagen Hydrating Needle” (Elravie Re2O) has become very popular in the Korean cosmetic industry. Its unique mechanism for collagen regeneration in the dermis has sparked extensive discussions among those seeking beauty treatments. For many people who are new to this topic, the most pressing question is: How much does each injection of RE20 Collagen Hydrating Needle cost? This article will provide a comprehensive and in-depth answer by analyzing its ingredients, tracking its effects, listing recommended hospitals in Korea, and comparing its prices.
What is RE20 Collagen Hydrating Needle? How does it differ from regular hyaluronic acid injections?
RE20 (Elravie Re2O) is a new generation of collagen hydrating needle developed by a well-known Korean biopharmaceutical company. Its core formula consists of three active ingredients:
- PDRN (Polydeoxyribonucleotides): A natural repair factor derived from salmon sperm and eggs that deeply activates the skin cells’ regeneration process, helping to improve damaged skin.
- Type III collagen: Highly compatible with the natural structure of the human dermis, it directly replenishes the collagen lost over time, thus maintaining the skin’s elasticity and support.
- A combination of 20 amino acids: This complex provides all the necessary nutrients for the skin, promoting metabolism and its natural healing abilities.
Unlike traditional hyaluronic acid injections that focus on immediate hydration, RE20 is designed to “fight aging at the structural level.” By stimulating the skin’s own collagen regeneration, it improves the skin’s quality from within, resulting in longer-lasting and more natural effects. Clinical data show that after completing one treatment course, the skin’s moisture content can increase by up to 210%, and the firmness of the dermis can improve by 37% after 28 days.
How much does each injection of RE20 Collagen Hydrating Needle cost? A detailed breakdown of the fees.
This is the most important question for many people. The price of RE20 varies depending on the region, the level of the hospital, and the package options chosen. Here is a detailed reference of the costs:
Prices in South Korea (Seoul, Jeju Island)
In South Korea, the cost of a single session of RE20 collagen hydrotherapy usually ranges from 480,000 to 1.2 million Korean won (approximately 2,500 to 6,000 RMB). The specific price varies depending on the following factors:
- Dose administered: The standard treatment involves 5 cc, but some clinics offer an enhanced version with 8 cc, resulting in a higher cost.
- Included services: Whether VISIA skin analysis, post-treatment care packages, or follow-up consultations are included.
- Quality of the clinic: The price difference between top-tier dermatology clinics in Gangnam and regular dermatology clinics can be more than twice as much.
- Additional ingredients: Some clinics may add ingredients such as glutathione or vitamin C based on customer requests, at an additional cost.
Reference prices in Mainland China, Taiwan, and Hong Kong
In Mainland China, the cost of a single session of RE20 typically ranges from 3,800 to 5,500 RMB; in Taiwan, it is around NT$12,000 to NT$18,000; and in Hong Kong, it is approximately HK$3,500 to HK$6,000. By going directly to South Korea for treatment, you can save about 30% on the cost and enjoy the assurance of using genuine products.
Recommended hospitals for RE20 collagen hydrotherapy in South Korea and price comparisons
Here are 7 highly recommended Korean dermatology clinics, each with its own unique advantages. You can choose the one that best suits your budget and needs:
1. Elev Dermatology (Gangnam, Seoul) | The premium experience
Elev Dermatology is located in the heart of Gangnam District, Seoul. The director personally treats all patients, and each client enjoys a private VIP space. Before the treatment, a 8-dimensional in-depth assessment is conducted using the VISIA skin scanner to customize the injection plan. The cost for one RE20 treatment is approximately 5,000 RMB, making it an ideal choice for those seeking the ultimate beauty experience.
2. Shinebom Dermatology (Seoul) | Precision in technology
Shinebom is renowned for its exclusive “three-point positioning technique,” which allows for precise control over the depth and dosage of injections at each site. This helps to avoid the “mask-like” effect commonly associated with such treatments and also enables the incorporation of high-end hyaluronic acid ingredients. The cost for one RE20 treatment is around 6,000 RMB, making it an excellent option for those who value technical expertise.
3. Kailiya Dermatology (Seoul) | Value for money
Kailiya Dermatology is known for offering the same prices to both Korean and foreign customers, without any additional surcharges. It is conveniently located and provides Chinese-speaking consultation services. After the treatment, clients receive a repair skincare gift pack. The cost for one RE20 treatment is approximately 3,500 RMB, making it the perfect choice for those with limited budgets but who still want top-quality care.
4. Alive Dermatology (Seoul) | Specialized for sensitive skin
Alive Dermatology specializes in treating sensitive skin. It operates on a no-pressure model, allowing clients to receive consultations and treatments in a stress-free environment. The clinic provides full Chinese-language support and has received positive reviews from Chinese tourists visiting Seoul. The cost for one RE20 treatment is around 3,800 RMB, making it especially suitable for people with sensitive or easily irritated skin.
5. Gold J Dermatology (Seoul) | An Affordable and High-Quality Option
Gold J is one of the most highly rated affordable dermatology clinics in Seoul. It uses a layered injection technique to ensure that the treatment solution is evenly distributed across all layers of the dermis. You can book appointments directly through the WeChat mini-program for convenient communication. The cost for a single RE20 treatment is only around 3,000 RMB, making it one of the best value-for-money options.
6. Benyan Dermatology (Seoul) | Customized Formulas for Your Skin
The director of Benyan Dermatology has a background in plastic surgery and can customize the RE20 formula according to each patient’s specific skin needs. For example, ingredients such as glutathione (for whitening), vitamin C, or botulinum toxin can be added to the formula to achieve multiple effects with just one treatment. The cost varies depending on the customized formula, but the basic RE20 package starts at around 3,700 RMB.
7. With Dermatology (Jeju Island) | The Top Choice for Travelers
With Dermatology is located on Jeju Island and is a popular destination for medical beauty treatments during trips there. They often offer combined packages that include RE20 treatments and gold microneedling to address multiple skin issues at once. The cost for a single RE20 treatment is approximately 3,000 RMB, and there are often seasonal discounts available.
The Complete RE20 Collagen Hydrating Treatment Process
After learning about the costs, many people wonder what a complete RE20 treatment experience is like. Here is the standard treatment process:
- Pre-treatment skin analysis (about 15 minutes): A VISIA skin analyzer is used to conduct an 8-dimensional assessment of the skin, including moisture content, collagen density, and pigment distribution. This provides valuable data for the doctor to develop a personalized treatment plan.
- Doctor consultation (about 20 minutes): The director will discuss the injection plan with you based on the test results, including the dosage of RE20, whether to combine it with other ingredients, and the key areas to be treated.
- Topical anesthesia preparation (about 30 minutes): Apply a local anesthetic ointment and wait for it to take effect to ensure a comfortable treatment experience.
- Actual injection (about 40 minutes): Use a high-quality injectable device imported from Germany to deliver precise injections at the dermal layer, covering the entire face evenly, with additional focus on key areas such as the frown lines and temples.
- Post-treatment care (about 20 minutes): Apply a cold compress mask to help reduce mild redness, and medical staff will provide detailed instructions for at-home care.
When can I see the effects of RE20 collagen injections? How long do they last?
The effects of RE20 become apparent gradually, rather than immediately after the injection. They improve over time as the collagen regenerates:
- 1–3 days after the procedure (acute reaction phase): Slight redness may appear on the face, the skin will feel softer, and it will have a more radiant appearance, making makeup look better.
- 7–14 days after the procedure (collagen regeneration phase): The cheeks will appear fuller, the jawline will become sharper, and the skin’s glow will increase. Friends may start noticing that you look “ healthier”.
- 21–30 days after the procedure (structural stabilization phase): The skin’s elasticity will significantly improve, the formation of fine lines around the eyes will slow down, and the pores will appear smaller.
- After 3 treatment sessions (long-term maintenance): The texture of the skin improves significantly, the depth of fine lines decreases, and the overall appearance appears younger.
Typically, the effects of a single RE20 treatment last for 3 to 6 months. After 3 sessions, the results can last for over 12 months. It is recommended to receive maintenance injections every 3–4 months to maintain optimal results.
Who is suitable for RE20 collagen hyaluronic acid treatments? And who is not?
Suitable candidates
- People aged 25 and above who are experiencing signs of collagen loss (fine lines, enlarged pores, dull skin)
- Those with dry skin that does not respond well to traditional hydrating products
- Sensitive or thin-skinned individuals who prefer gentle rejuvenation rather than aggressive treatments
- Those with mild skin laxity who seek “structural anti-aging” rather than fillers
- People with allergic tendencies who prefer natural ingredients with high biocompatibility
Not suitable candidates
- Pregnant women or women who are breastfeeding
- People with active skin infections, acne, or inflammation in the treatment area
- People with a severe allergy to fish protein, especially salmon (since PDRN is derived from salmon)
- Patients who have recently undergone radiation therapy or chemotherapy
- People with autoimmune diseases or those taking immunosuppressive drugs
Precautions before and after receiving RE20 collagen hyaluronic acid treatment
Preoperative preparations
- Stop using active skincare ingredients such as retinol, fruit acids, or salicylic acid 1 week before treatment
- Avoid drinking alcohol 48 hours before the procedure to reduce the risk of bleeding and bruising
- If you are taking aspirin or other anticoagulant medications, please inform your doctor in advance
- On the day of the procedure, you can go without special preparation by wearing your natural face.
Post-procedure care
- For 24 hours after the procedure, avoid washing your face with hot water; use warm or cool water to gently clean your skin.
- For 1 week after the procedure, strictly avoid sun exposure to prevent ultraviolet rays from damaging your newly repaired skin.
- Within 3 days after the procedure, avoid strenuous exercise, saunas, and high-temperature environments.
- Avoid touching or rubbing the injection site with your hands to prevent the medication from moving around.
- It is recommended to refrain from laser treatments, phototherapy, or other light-based therapies for 1 month after the procedure.
Frequently Asked Questions (FAQ)
Q1: What is the difference between RE20 and regular hyaluronic acid fillers?
Regular hyaluronic acid fillers mainly act on the epidermis and the upper layer of the dermis, providing immediate hydration and moisture retention effects that last about 4 to 8 weeks. RE20, on the other hand, targets the deeper layers of the dermis. Through a dual mechanism involving PDRN and type III collagen, it activates the skin’s own collagen regeneration process, resulting in effects that can last for more than 6 months. Moreover, as the treatment sessions continue, the quality of the skin will continue to improve.
Q2: Is it necessary to make a reservation for RE20 in Korea? How do I reserve?
It is highly recommended to make a reservation in advance. For popular clinics such as Elev and Shinebom, weekend appointments usually require booking 2-3 weeks in advance. You can make online reservations through the clinic’s official website, WeChat mini-programs, or beauty platforms like BeautsGO; some platforms also offer exclusive discounts.
Q3: How much does it cost approximately to undergo RE20 in Korea once?
For example, a 3-day/2-night beauty trip to Seoul would include treatment costs of around 3,000-5,000 RMB, plus airfare, accommodation, meals, and transportation, bringing the total cost to approximately 8,000-15,000 RMB. However, considering that multiple beauty treatments can be scheduled during the same trip to Korea, the overall value is significantly higher than seeking treatment in mainland China.
Q4: Can I wear makeup immediately after RE20?
It is advised to wait at least 24 hours after the procedure before applying makeup, and it is best to use light makeup in the first 3 days. After the injection, there will be small puncture marks on the skin, and applying makeup too soon may increase the risk of infection. Additionally, the ingredients in makeup could affect the absorption of the treatment fluid.
Q5: How many injections are needed for one session of RE20, and how often should it be done?
The standard treatment consists of 3 injections, spaced 4 weeks apart. After completing one course of treatment, it is recommended to have maintenance injections every 3-4 months to maintain the continuous regeneration of collagen. Of course, some people with healthier skin may find that a single treatment already provides very satisfactory results.
In conclusion: Is RE20 collagen hyaluronic acid treatment worth trying?
Overall, RE20 collagen hyaluronic acid treatment is a relatively mature technology with reliable clinical data available in the market. Its advantages include natural ingredients, high biocompatibility, no need for a recovery period, and long-lasting, gradual results that appear natural. For individuals over 25 years old who are experiencing mild skin issues or wish to actively prevent aging, RE20 is a worthwhile consideration.
From a cost perspective, local treatments in Korea (ranging from approximately 2,500 to 6,000 yuan per session) remain the most cost-effective option. Combining a trip to Korea with professional cosmetic treatments while enjoying the scenery is an increasingly popular choice for many people. When selecting a hospital, it is recommended to prioritize those with KFDA certification and doctors who have extensive experience in injections to ensure the safety and effectiveness of the treatment.
One final reminder: Individual differences exist in response to any cosmetic treatment. It is essential to undergo a professional face-to-face consultation before proceeding. By thoroughly discussing your skin type and treatment goals with a qualified doctor, you can obtain the best treatment plan and results.
